How to Prevent Heart Disease with Mitochondria, Muscle, and the Endothelial Glycocalyx | Dr. Michael Twyman

Did you know every 40 seconds someone in the U.S. has a heart attack—and 1 in 5 never even see it coming? This week, I am joined by preventive cardiologist Dr. Michael Twyman as we discuss cutting-edge diagnostics, the endothelial glycocalyx, nitric oxide biology, and why muscle mass is your heart’s best friend. Learn the practical steps and questions to ask to protect your heart before symptoms appear.

Together, we explore:

Why silent heart attacks are so prevalentThe role of nitric oxide and the endothelial glycocalyx in vascular healthThe critical link between muscle mass, VO₂ max, and heart resilienceHow advanced imaging and testing are changing preventionDebunking common myths around cardiovascular riskSupplements and diagnostics Dr. Twyman uses to optimize cardiovascular health

This episode is a masterclass in heart disease prevention—don’t miss it.

Who is Dr. Michael Twyman

Dr. Twyman is a board-certified cardiologist specializing in early detection and prevention of cardiovascular disease. Founder of Apollo Cardiology in St. Louis, he’s recognized for integrating advanced arterial imaging, mitochondrial health strategies, and personalized medicine to optimize long-term heart health. Dr. Twyman’s mission is to educate his patients on how to live better and longer by optimizing their mitochondrial function to become heart attack proof.

This episode is brought to you by:

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Find Michael Twyman at:

Website - https://drtwyman.com/ Apollo Cardiology - https://drtwyman.com/apollocardiology/LinkedIn - https://www.linkedin.com/in/drtwyman/Instagram - https://www.instagram.com/drtwyman/X (Twitter) - https://x.com/michaeltwymanmd

Find Me At:

Instagram:@drgabriellelyon  TikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter –

The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.

• No. of episodes: 163
• Latest episode: 2025-07-15
• Health & Fitness Science Medicine Life Sciences

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